Metabolic reprogramming is emerging as a hallmark of the innate immune response, and
the dynamic control of metabolites such as succinate serves to facilitate the execution of
inflammatory responses in macrophages and other immune cells. Immunoresponsive gene
1 (Irg1) expression is induced by inflammatory stimuli, and its enzyme product cis-aconitate
decarboxylase catalyzes the production of itaconate from the tricarboxylic acid cycle. Here
we identify an immunometabolic regulatory pathway that links Irg1 and itaconate production …