Structural analysis of the outer surface proteins from Borrelia burgdorferi paralogous gene family 54 that are thought to be the key players in the pathogenesis of Lyme …
K Brangulis, I Akopjana, I Petrovskis, A Kazaks… - Journal of structural …, 2020 - Elsevier
Lyme disease is a tick-borne infection caused by Borrelia burgdorferi sensu lato complex
spirochetes. Through a complex enzootic cycle, the bacteria transfer between two different
hosts: Ixodes ticks and mammalian organisms. At the start of the tick blood meal, the
spirochetes located in the tick gut upregulate the expression of several genes, mainly coding
for outer surface proteins. Outer surface proteins belonging to the paralogous gene family 54
(PFam54) have been shown to be the most upregulated among the other borrelial proteins …
spirochetes. Through a complex enzootic cycle, the bacteria transfer between two different
hosts: Ixodes ticks and mammalian organisms. At the start of the tick blood meal, the
spirochetes located in the tick gut upregulate the expression of several genes, mainly coding
for outer surface proteins. Outer surface proteins belonging to the paralogous gene family 54
(PFam54) have been shown to be the most upregulated among the other borrelial proteins …