[HTML][HTML] Blunted evoked prouroguanylin endocrine secretion in chronic constipation
SA Waldman, R Tenenbaum, HC Foehl… - Clinical and …, 2019 - journals.lww.com
OBJECTIVES: Prouroguanylin (ProUGN) in the intestine is cleaved to form uroguanylin
(UGN), which stimulates guanylate cyclase C (GUCY2C), inducing cyclic guanosine
monophosphate signaling. Paracrine release regulates fluid secretion, contributing to bowel
function, whereas endocrine secretion evoked by eating forms a gut-brain axis, controlling
appetite. Whereas hormone insufficiency contributes to hyperphagia in obesity, its
contribution to the pathophysiology of constipation syndromes remains unexplored. Here …
(UGN), which stimulates guanylate cyclase C (GUCY2C), inducing cyclic guanosine
monophosphate signaling. Paracrine release regulates fluid secretion, contributing to bowel
function, whereas endocrine secretion evoked by eating forms a gut-brain axis, controlling
appetite. Whereas hormone insufficiency contributes to hyperphagia in obesity, its
contribution to the pathophysiology of constipation syndromes remains unexplored. Here …