[HTML][HTML] Histone deacetylase-3 activation promotes tumor necrosis factor-α (TNF-α) expression in cardiomyocytes during lipopolysaccharide stimulation

H Zhu, L Shan, PW Schiller, A Mai, T Peng - Journal of Biological Chemistry, 2010 - ASBMB
Lipopolysaccharides (LPS) induce tumor necrosis factor-α (TNF-α) production in
cardiomyocytes, which contributes to myocardial depression during sepsis. However, the
underlying mechanisms remain not fully understood. This study was undertaken to
investigate the contribution of histone deacetylase (HDAC) to TNF-α expression in
cardiomyocytes and the signaling mechanism of LPS-induced HDAC activation. Here, we
show for the first time that LPS increases HDAC activity and that inhibition of HDAC …