Tolerance to innocuous antigens from the diet and the commensal microbiota is a
fundamental process essential to health. Why tolerance is efficiently induced to substances
arising from the hostile environment of the gut lumen is incompletely understood but may be
related to how these antigens are encountered by the immune system. We observed that
goblet cell associated antigen passages (GAPs), but not other pathways of luminal antigen
capture, correlated with the acquisition of luminal substances by lamina propria (LP) antigen …