SUMO and the robustness of cancer
JS Seeler, A Dejean - Nature Reviews Cancer, 2017 - nature.com
JS Seeler, A Dejean
Nature Reviews Cancer, 2017•nature.comPost-translational protein modification by small ubiquitin-like modifier (SUMO), termed
sumoylation, is an important mechanism in cellular responses to stress and one that
appears to be upregulated in many cancers. Here, we examine the role of sumoylation in
tumorigenesis as a possibly necessary safeguard that protects the stability and functionality
of otherwise easily misregulated gene expression programmes and signalling pathways of
cancer cells.
sumoylation, is an important mechanism in cellular responses to stress and one that
appears to be upregulated in many cancers. Here, we examine the role of sumoylation in
tumorigenesis as a possibly necessary safeguard that protects the stability and functionality
of otherwise easily misregulated gene expression programmes and signalling pathways of
cancer cells.
Abstract
Post-translational protein modification by small ubiquitin-like modifier (SUMO), termed sumoylation, is an important mechanism in cellular responses to stress and one that appears to be upregulated in many cancers. Here, we examine the role of sumoylation in tumorigenesis as a possibly necessary safeguard that protects the stability and functionality of otherwise easily misregulated gene expression programmes and signalling pathways of cancer cells.
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