The atopic march and atopic multimorbidity: many trajectories, many pathways
AS Paller, JM Spergel, P Mina-Osorio… - Journal of Allergy and …, 2019 - Elsevier
The atopic march recognizes the increased occurrence of asthma, allergic rhinitis, or both
after atopic dermatitis (AD) onset. Mechanisms for developing atopic comorbidities after AD
onset are poorly understood but can involve the impaired cutaneous barrier, which facilitates
cutaneous sensitization. The association can also be driven or amplified in susceptible
subjects by a systemic TH 2-dominant immune response to cutaneous inflammation.
However, these associations might merely involve shared genetic loci and environmental …
after atopic dermatitis (AD) onset. Mechanisms for developing atopic comorbidities after AD
onset are poorly understood but can involve the impaired cutaneous barrier, which facilitates
cutaneous sensitization. The association can also be driven or amplified in susceptible
subjects by a systemic TH 2-dominant immune response to cutaneous inflammation.
However, these associations might merely involve shared genetic loci and environmental …