[HTML][HTML] Phosphorylation of the cryptochrome 1 C-terminal tail regulates circadian period length
P Gao, SH Yoo, KJ Lee, C Rosensweig… - Journal of Biological …, 2013 - ASBMB
The Cryptochrome (CRY) proteins are critical components of the mammalian circadian clock
and act to rhythmically repress the activity of the transcriptional activators CLOCK and
BMAL1 at the heart of the clock mechanism. The CRY proteins are part of a large repressive
complex, the components of which are not completely known. Using mass spectroscopy, we
identified the catalytic subunit of DNA-dependent protein kinase as a CRY-interacting
protein and found that loss or inhibition of this kinase results in circadian rhythms with …
and act to rhythmically repress the activity of the transcriptional activators CLOCK and
BMAL1 at the heart of the clock mechanism. The CRY proteins are part of a large repressive
complex, the components of which are not completely known. Using mass spectroscopy, we
identified the catalytic subunit of DNA-dependent protein kinase as a CRY-interacting
protein and found that loss or inhibition of this kinase results in circadian rhythms with …