Rapamycin attenuates mouse liver ischemia and reperfusion injury by inhibiting endoplasmic reticulum stress
J Zhu, X Hua, D Li, J Zhang, Q Xia - Transplantation proceedings, 2015 - Elsevier
The roles of endoplasmic reticulum (ER) stress in liver ischemia and reperfusion injury (IRI)
have been well recognized. However, the impact of rapamycin (Rapa), a broadly used
immunosuppressive agent in human liver transplantation, on ER stress during IRI remains
unclear. This study was designed to investigate the roles of Rapa in the regulation of ER
stress in vivo and in vitro. In a mouse liver partial warm ischemia and reperfusion mode, we
demonstrated that Rapa markedly protected livers from IRI, as evidenced by serum alanine …
have been well recognized. However, the impact of rapamycin (Rapa), a broadly used
immunosuppressive agent in human liver transplantation, on ER stress during IRI remains
unclear. This study was designed to investigate the roles of Rapa in the regulation of ER
stress in vivo and in vitro. In a mouse liver partial warm ischemia and reperfusion mode, we
demonstrated that Rapa markedly protected livers from IRI, as evidenced by serum alanine …