[HTML][HTML] Neutrophil extracellular trap fragments stimulate innate immune responses that prevent lung transplant tolerance
Neutrophil extracellular traps (NETs) have been shown to worsen acute pulmonary injury
including after lung transplantation. The breakdown of NETs by DNAse-1 can help restore
lung function, but whether there is an impact on allograft tolerance remains less clear. Using
intravital 2-photon microscopy, we analyzed the effects of DNAse-1 on NETs in mouse
orthotopic lung allografts damaged by ischemia-reperfusion injury. Although DNAse-1
treatment rapidly degrades intragraft NETs, the consequential release of NET fragments …
including after lung transplantation. The breakdown of NETs by DNAse-1 can help restore
lung function, but whether there is an impact on allograft tolerance remains less clear. Using
intravital 2-photon microscopy, we analyzed the effects of DNAse-1 on NETs in mouse
orthotopic lung allografts damaged by ischemia-reperfusion injury. Although DNAse-1
treatment rapidly degrades intragraft NETs, the consequential release of NET fragments …