[HTML][HTML] Regulation of autophagy and its associated cell death by “sphingolipid rheostat”: reciprocal role of ceramide and sphingosine 1-phosphate in the mammalian …
M Taniguchi, K Kitatani, T Kondo… - Journal of Biological …, 2012 - ASBMB
The role of" sphingolipid rheostat" by ceramide and sphingosine 1-phosphate (S1P) in the
regulation of autophagy remains unclear. In human leukemia HL-60 cells, amino acid
deprivation (AA (−)) caused autophagy with an increase in acid sphingomyleinase (SMase)
activity and ceramide, which serves as an autophagy inducing lipid. Knockdown of acid
SMase significantly suppressed the autophagy induction. S1P treatment counteracted
autophagy induction by AA (−) or C 2-ceramide. AA (−) treatment promoted mammalian …
regulation of autophagy remains unclear. In human leukemia HL-60 cells, amino acid
deprivation (AA (−)) caused autophagy with an increase in acid sphingomyleinase (SMase)
activity and ceramide, which serves as an autophagy inducing lipid. Knockdown of acid
SMase significantly suppressed the autophagy induction. S1P treatment counteracted
autophagy induction by AA (−) or C 2-ceramide. AA (−) treatment promoted mammalian …