Angiogenesis in vitro
J Folkman, C Haudenschild - Nature, 1980 - nature.com
J Folkman, C Haudenschild
Nature, 1980•nature.comCloned capillary endothelial cells, cultured in tumour-conditioned medium, form capillary
tubes. By light and electron microscopy these tubes resemble capillaries in vivo. This first
demonstration of angiogenesis in vitro:(1) shows that all the information necessary to
develop an entire capillary network in vitro is expressed by one cell type;(2) suggests a
mechanism for lumen formation; and (3) offers a possibility of distinguishing between direct
and indirect angiogenesis factors.
tubes. By light and electron microscopy these tubes resemble capillaries in vivo. This first
demonstration of angiogenesis in vitro:(1) shows that all the information necessary to
develop an entire capillary network in vitro is expressed by one cell type;(2) suggests a
mechanism for lumen formation; and (3) offers a possibility of distinguishing between direct
and indirect angiogenesis factors.
Abstract
Cloned capillary endothelial cells, cultured in tumour-conditioned medium, form capillary tubes. By light and electron microscopy these tubes resemble capillaries in vivo. This first demonstration of angiogenesis in vitro: (1) shows that all the information necessary to develop an entire capillary network in vitro is expressed by one cell type; (2) suggests a mechanism for lumen formation; and (3) offers a possibility of distinguishing between direct and indirect angiogenesis factors.
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