[HTML][HTML] The C-terminal region of an Apg7p/Cvt2p is required for homodimerization and is essential for its E1 activity and E1-E2 complex formation
M Komatsu, I Tanida, T Ueno, M Ohsumi… - Journal of Biological …, 2001 - ASBMB
Apg7p/Cvt2p, a protein-activating enzyme, is essential for both the Apg12p-Apg5p
conjugation system and the Apg8p membrane targeting in autophagy and cytoplasm-to-
vacuole targeting in the yeast Saccharomyces cerevisiae. Similar to the ubiquitin-
conjugating system, both Apg12p and Apg8p are activated by Apg7p, an E1-like enzyme.
Apg12p is then transferred to Apg10p, an E2-like enzyme, and conjugated with Apg5p,
whereas Apg8p is transferred to Apg3p, another E2-like enzyme, followed by conjugation …
conjugation system and the Apg8p membrane targeting in autophagy and cytoplasm-to-
vacuole targeting in the yeast Saccharomyces cerevisiae. Similar to the ubiquitin-
conjugating system, both Apg12p and Apg8p are activated by Apg7p, an E1-like enzyme.
Apg12p is then transferred to Apg10p, an E2-like enzyme, and conjugated with Apg5p,
whereas Apg8p is transferred to Apg3p, another E2-like enzyme, followed by conjugation …