Transnitrosylation and denitrosylation are emerging as key post-translational modification
events in regulating both normal physiology and a wide spectrum of human diseases.
Thioredoxin 1 (Trx1) is a conserved antioxidant that functions as a classic disulfide
reductase. It also catalyzes the transnitrosylation or denitrosylation of caspase 3 (Casp3),
underscoring its central role in determining Casp3 nitrosylation specificity. However, the
mechanisms that regulate Trx1 transnitrosylation and denitrosylation of specific targets are …