Several distinct properties of the IgE repertoire determine effector cell degranulation in response to allergen challenge
LH Christensen, J Holm, G Lund, E Riise… - Journal of Allergy and …, 2008 - Elsevier
BACKGROUND: On cross-linking of receptor-bound IgE antibodies by allergens, effector
cells (basophils and mast cells) involved in type I allergic reactions degranulate and release
the potent chemical mediators stored inside their granules. Total and allergen-specific IgE
concentrations, IgE affinity for allergen, and IgE clonality are all distinct properties of allergic
patients' IgE repertoires. However, the inability to isolate individual IgE antibodies from
allergic patients' sera presents a major barrier to understanding the importance of patient …
cells (basophils and mast cells) involved in type I allergic reactions degranulate and release
the potent chemical mediators stored inside their granules. Total and allergen-specific IgE
concentrations, IgE affinity for allergen, and IgE clonality are all distinct properties of allergic
patients' IgE repertoires. However, the inability to isolate individual IgE antibodies from
allergic patients' sera presents a major barrier to understanding the importance of patient …