Early epitope-specific IgE antibodies are predictive of childhood peanut allergy
Background Peanut allergy is characterized by the development of IgE against peanut
antigen. Objective We sought to evaluate the evolution of epitope-specific (es) IgE and
esIgG 4 in a prospective cohort of high-risk infants to determine whether antibody profiles
can predict peanut allergy after age 4 years. Methods The end point was allergy status at
age 4+ years; samples from 293 children were collected at age 3 to 15 months and 2 to 3
and 4+ years. Levels of specific (s) IgE and sIgG 4 to peanut and component proteins, and …
antigen. Objective We sought to evaluate the evolution of epitope-specific (es) IgE and
esIgG 4 in a prospective cohort of high-risk infants to determine whether antibody profiles
can predict peanut allergy after age 4 years. Methods The end point was allergy status at
age 4+ years; samples from 293 children were collected at age 3 to 15 months and 2 to 3
and 4+ years. Levels of specific (s) IgE and sIgG 4 to peanut and component proteins, and …