EGFR mutation is specific for terminal respiratory unit type adenocarcinoma
Y Yatabe, T Kosaka, T Takahashi… - The American journal of …, 2005 - journals.lww.com
We have previously reported that terminal-respiratory-unit (TRU) type adenocarcinoma is a
distinct subset of lung adenocarcinoma in terms of molecular pathway for carcinogenesis
and phenotypic profiles. This type of cancer shows TRU features, characterized by distinct
cellular morphology and the expression of TTF-1 and surfactant proteins. Recently, two
groups published novel mutations of the epidermal growth factor receptor (EGFR) that are
closely associated with clinical response to gefitinib. The clinicopathologic features of …
distinct subset of lung adenocarcinoma in terms of molecular pathway for carcinogenesis
and phenotypic profiles. This type of cancer shows TRU features, characterized by distinct
cellular morphology and the expression of TTF-1 and surfactant proteins. Recently, two
groups published novel mutations of the epidermal growth factor receptor (EGFR) that are
closely associated with clinical response to gefitinib. The clinicopathologic features of …