Importance Although anti–vascular endothelial growth factor treatment of neovascular age-
related macular degeneration (AMD) results in improved vision overall, loss of substantial
vision can occur. Understanding the processes that lead to loss of vision may lead to
preventive strategies. Objective To determine the incidence, characteristics, causes, and
baseline predictors of sustained visual acuity loss after 2 years of treatment with
ranibizumab or bevacizumab for neovascular AMD. Design, Setting, and Participants A …