Inhibition of indoleamine 2, 3-dioxygenase 1/2 prevented cognitive impairment and energetic metabolism changes in the hippocampus of adult rats subjected to …
CM Comim, V Freiberger, L Ventura, F Mina… - Journal of …, 2017 - Elsevier
Sepsis is a life-threatening organ dysfunction caused by a dysregulated host response to
infection that may affect the brain. We investigated the role of indoleamine 2, 3-dioxygenase
(IDO-1/2) inhibition on long-term memory and energetic metabolism after experimental
sepsis by caecal ligation and perforation (CLP). Experimental sepsis increased the activity of
complexes I, II-III and IV at 24 h after CLP, and IDO-1/2 inhibition normalized the activity of
these complexes in the hippocampus. Wistar rats presented impairment of habituation and …
infection that may affect the brain. We investigated the role of indoleamine 2, 3-dioxygenase
(IDO-1/2) inhibition on long-term memory and energetic metabolism after experimental
sepsis by caecal ligation and perforation (CLP). Experimental sepsis increased the activity of
complexes I, II-III and IV at 24 h after CLP, and IDO-1/2 inhibition normalized the activity of
these complexes in the hippocampus. Wistar rats presented impairment of habituation and …