Evaluation of peripheral blood T lymphocyte surface activation markers and transcription factors in patients with early stage non-small cell lung cancer
J Rutkowski, M Cyman, T Ślebioda, K Bemben… - Cellular …, 2017 - Elsevier
Lung cancer cells harboring multiple mutations as a consequence of long-term damage by
different etiologic factors are responsible for high immunogenicity. Immune checkpoint
inhibitors significantly improve treatment results in non-small cell lung cancer (NSCLC).
Unfortunately, the role of T-lymphocytes in early NSCLC has not been sufficiently elucidated.
The aim of this study was to characterize peripheral blood T cells expressing several
selected surface antigens (CD4, CD8, CD25, CD28, PD-1, CTLA-4) and transcription factors …
different etiologic factors are responsible for high immunogenicity. Immune checkpoint
inhibitors significantly improve treatment results in non-small cell lung cancer (NSCLC).
Unfortunately, the role of T-lymphocytes in early NSCLC has not been sufficiently elucidated.
The aim of this study was to characterize peripheral blood T cells expressing several
selected surface antigens (CD4, CD8, CD25, CD28, PD-1, CTLA-4) and transcription factors …