Neuronal activity in the glioma microenvironment
T Johung, M Monje - Current opinion in neurobiology, 2017 - Elsevier
T Johung, M Monje
Current opinion in neurobiology, 2017•ElsevierHighlights•Neuronal activity promotes glioma growth.•Gliomas increase neuronal excitability
and promote seizures.•Bidirectional communication between gliomas and neurons in the
tumor microenvironment drives a cycle of malignancy.Gliomas are the most common primary
brain tumor and high-grade gliomas the leading cause of brain tumor-related death in both
children and adults. An appreciation for the crucial role of the nervous system in the tumor
microenvironment is emerging for cancers in general, and the neural regulation of glioma …
and promote seizures.•Bidirectional communication between gliomas and neurons in the
tumor microenvironment drives a cycle of malignancy.Gliomas are the most common primary
brain tumor and high-grade gliomas the leading cause of brain tumor-related death in both
children and adults. An appreciation for the crucial role of the nervous system in the tumor
microenvironment is emerging for cancers in general, and the neural regulation of glioma …
Highlights
- Neuronal activity promotes glioma growth.
- Gliomas increase neuronal excitability and promote seizures.
- Bidirectional communication between gliomas and neurons in the tumor microenvironment drives a cycle of malignancy.
Gliomas are the most common primary brain tumor and high-grade gliomas the leading cause of brain tumor-related death in both children and adults. An appreciation for the crucial role of the nervous system in the tumor microenvironment is emerging for cancers in general, and the neural regulation of glioma progression has come into sharp focus. Here, we review what is known about the influence of active neurons on glioma pathobiology.
Elsevier