New roles for TIM family members in immune regulation
VK Kuchroo, V Dardalhon, S Xiao… - Nature Reviews …, 2008 - nature.com
VK Kuchroo, V Dardalhon, S Xiao, AC Anderson
Nature Reviews Immunology, 2008•nature.comMembers of the TIM (T-cell immunoglobulin domain and mucin domain) protein family are
emerging as important regulators of immune responses. As their names imply, the TIM
proteins were originally thought to be T-cell-specific molecules that served mainly to
regulate T-helper-cell responses. However, the recent discovery that antigen-presenting
cells also express TIM molecules and the identification of new TIM-protein ligands has
expanded the known roles of the TIM proteins in immune regulation.
emerging as important regulators of immune responses. As their names imply, the TIM
proteins were originally thought to be T-cell-specific molecules that served mainly to
regulate T-helper-cell responses. However, the recent discovery that antigen-presenting
cells also express TIM molecules and the identification of new TIM-protein ligands has
expanded the known roles of the TIM proteins in immune regulation.
Abstract
Members of the TIM (T-cell immunoglobulin domain and mucin domain) protein family are emerging as important regulators of immune responses. As their names imply, the TIM proteins were originally thought to be T-cell-specific molecules that served mainly to regulate T-helper-cell responses. However, the recent discovery that antigen-presenting cells also express TIM molecules and the identification of new TIM-protein ligands has expanded the known roles of the TIM proteins in immune regulation.
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