Adaptive features of innate immunity, also termed 'trained immunity', have recently been
shown to characterize monocytes of BCG vaccinated healthy volunteers. Trained immunity
leads to increased cytokine production in response to non-related pathogens via epigenetic
reprogramming of monocytes. Recently, memory-like properties were also observed in NK
cells during viral infections, but it is unknown if memory properties of NK cells contribute to
trained immunity due to BCG vaccination. BCG vaccination of healthy volunteers increased …