Lipid composition of human intracranial tumors: a biochemical study

K Gopal, E Grossi, P Paoletti, M Usardi - Acta neurochirurgica, 1963 - Springer
K Gopal, E Grossi, P Paoletti, M Usardi
Acta neurochirurgica, 1963Springer
The lipid composition of different types of human intracranial tumors, including gliomas,
meningeomas and neurinomas, and of adult human brain tissue was analyzed. Gliomas
have a higher lipid content than have the other tumors, but a lower lipid content than normal
nervous tissue. Intracranial tumors have a relatively high quantity of sterol-esters, glycerol-
esters and free fattyacids, besides free sterols and non-dialysable lipids. The fatty acid
pattern from the different lipid classes has been established using a gas chromatographic …
Summary
The lipid composition of different types of human intracranial tumors, including gliomas, meningeomas and neurinomas, and of adult human brain tissue was analyzed.
Gliomas have a higher lipid content than have the other tumors, but a lower lipid content than normal nervous tissue. Intracranial tumors have a relatively high quantity of sterol-esters, glycerol-esters and free fattyacids, besides free sterols and non-dialysable lipids.
The fatty acid pattern from the different lipid classes has been established using a gas chromatographic technique. Some interesting differences have been found between the different types of tumors, and between tumors and normal nervous tissue.
Phospholipids were fractionated into four classes: in intracranial tumors a relatively high percentage of lecithins, with smaller percentages of cephalins, sphingomyelins and lysolecithins have been found.
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