[HTML][HTML] CD22 forms a quaternary complex with SHIP, Grb2, and Shc: a pathway for regulation of B lymphocyte antigen receptor-induced calcium flux
JC Poe, M Fujimoto, PJ Jansen, AS Miller… - Journal of Biological …, 2000 - ASBMB
CD22 is a cell surface molecule that regulates signal transduction in B lymphocytes.
Tyrosine-phosphorylated CD22 recruits numerous cytoplasmic effector molecules including
SHP-1, a potent phosphotyrosine phosphatase that down-regulates B cell antigen receptor
(BCR)-and CD19-generated signals. Paradoxically, B cells from CD22-deficient mice
generate augmented intracellular calcium responses following BCR ligation, yet proliferation
is decreased. To understand further the mechanisms through which CD22 regulates BCR …
Tyrosine-phosphorylated CD22 recruits numerous cytoplasmic effector molecules including
SHP-1, a potent phosphotyrosine phosphatase that down-regulates B cell antigen receptor
(BCR)-and CD19-generated signals. Paradoxically, B cells from CD22-deficient mice
generate augmented intracellular calcium responses following BCR ligation, yet proliferation
is decreased. To understand further the mechanisms through which CD22 regulates BCR …