Mechanisms underlying genetic susceptibility to multisystem inflammatory syndrome in children (MIS-C)
Background Multisystem inflammatory syndrome in children (MIS-C) is a pediatric
complication of severe acute respiratory syndrome coronavirus 2 infection that is
characterized by multiorgan inflammation and frequently by cardiovascular dysfunction. It
occurs predominantly in otherwise healthy children. We previously reported
haploinsufficiency of suppressor of cytokine signaling 1 (SOCS1), a negative regulator of
type I and II interferons, as a genetic risk factor for MIS-C. Objectives We aimed to identify …
complication of severe acute respiratory syndrome coronavirus 2 infection that is
characterized by multiorgan inflammation and frequently by cardiovascular dysfunction. It
occurs predominantly in otherwise healthy children. We previously reported
haploinsufficiency of suppressor of cytokine signaling 1 (SOCS1), a negative regulator of
type I and II interferons, as a genetic risk factor for MIS-C. Objectives We aimed to identify …