SARS-CoV-2-specific T cell responses in patients with multisystem inflammatory syndrome in children
Multisystem inflammatory syndrome in children (MIS-C) is a severe complication of SARS-
CoV-2 infections that occurs in the pediatric population. We sought to characterize T cell
responses in MIS-C compared to COVID-19 and pediatric hyperinflammatory syndromes.
MIS-C was distinct from COVID-19 and hyperinflammatory syndromes due to an expansion
of T cells expressing TRBV11–2 that was not associated with HLA genotype. Children
diagnosed with MIS-C, but who were negative for SARS-CoV-2 by PCR and serology, did …
CoV-2 infections that occurs in the pediatric population. We sought to characterize T cell
responses in MIS-C compared to COVID-19 and pediatric hyperinflammatory syndromes.
MIS-C was distinct from COVID-19 and hyperinflammatory syndromes due to an expansion
of T cells expressing TRBV11–2 that was not associated with HLA genotype. Children
diagnosed with MIS-C, but who were negative for SARS-CoV-2 by PCR and serology, did …