High-frequency stimulation in the ventral posterolateral thalamus reverses electrophysiologic changes and hyperalgesia in a rat model of peripheral neuropathic pain
M Iwata, BW LeBlanc, LM Kadasi, ML Zerah… - Pain, 2011 - Elsevier
Chronic neuropathic pain is associated with long-term changes at multiple levels of the
neuroaxis, including in the brain, where electrical stimulation has been used to manage
severe pain conditions. However, the clinical outcome of deep brain stimulation is often
mixed, and the mechanisms are poorly understood. By means of electrophysiologic
methods, we sought to characterize the changes in neuronal activity in the ventral
posterolateral nucleus of the thalamus (VPL) in a rat model of peripheral neuropathic pain …
neuroaxis, including in the brain, where electrical stimulation has been used to manage
severe pain conditions. However, the clinical outcome of deep brain stimulation is often
mixed, and the mechanisms are poorly understood. By means of electrophysiologic
methods, we sought to characterize the changes in neuronal activity in the ventral
posterolateral nucleus of the thalamus (VPL) in a rat model of peripheral neuropathic pain …