The muscarinic cholinergic receptor system has been implicated in the pathophysiology of
depression, with physiological evidence indicating this system is overactive or
hyperresponsive in depression and with genetic evidence showing that variation in genes
coding for receptors within this system are associated with higher risk for depression. In
studies aimed at assessing whether a reduction in muscarinic cholinergic receptor function
would improve depressive symptoms, the muscarinic receptor antagonist scopolamine …