What we have learned about pancreatic cancer from mouse models
PA Pérez–Mancera, C Guerra, M Barbacid… - …, 2012 - gastrojournal.org
Pancreatic ductal adenocarcinoma (PDA) is one of the most devastating malignancies
worldwide. A total of 43,140 new cases (ranked 10th) and 36,800 deaths (ranked 4th) from
pancreatic cancer were estimated to occur in the United States during 2010, with an overall
5-year survival rate of just 6%. 1 This dire clinical situation exists despite recent advances in
our understanding of the genetics and biology of PDA. Most patients with advanced PDA
either do not respond, or respond only transiently, to systemic chemotherapy and …
worldwide. A total of 43,140 new cases (ranked 10th) and 36,800 deaths (ranked 4th) from
pancreatic cancer were estimated to occur in the United States during 2010, with an overall
5-year survival rate of just 6%. 1 This dire clinical situation exists despite recent advances in
our understanding of the genetics and biology of PDA. Most patients with advanced PDA
either do not respond, or respond only transiently, to systemic chemotherapy and …