Dominant negative regulation of the mouse α-fetoprotein gene in adult liver
J Vacher, SM Tilghman - Science, 1990 - science.org
J Vacher, SM Tilghman
Science, 1990•science.orgTranscription of the mouse α-fetoprotein gene is activated in the developing fetal liver and
gut and repressed in both tissues shortly after birth. With germline transformation in mice, a
cis-acting element was identified upstream of the transcription initiation site of the α-
fetoprotein gene that was responsible for repression of the gene in adult liver. This negative
element acts as a repressor in a position-dependent manner.
gut and repressed in both tissues shortly after birth. With germline transformation in mice, a
cis-acting element was identified upstream of the transcription initiation site of the α-
fetoprotein gene that was responsible for repression of the gene in adult liver. This negative
element acts as a repressor in a position-dependent manner.
Transcription of the mouse α-fetoprotein gene is activated in the developing fetal liver and gut and repressed in both tissues shortly after birth. With germline transformation in mice, a cis-acting element was identified upstream of the transcription initiation site of the α-fetoprotein gene that was responsible for repression of the gene in adult liver. This negative element acts as a repressor in a position-dependent manner.
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