Use of β-blockers and risk of fractures

RG Schlienger, ME Kraenzlin, SS Jick, CR Meier - Jama, 2004 - jamanetwork.com
ContextAnimal studies suggest that the β-blocker propranolol increases bone formation, but
data on whether use of β-blockers (with or without concomitant use of thiazide diuretics) is
associated with reduced fracture risk in humans are limited. ObjectiveTo determine whether
use of β-blockers alone or in combination with thiazides is associated with a decreased risk
of fracture in adults. Design, Setting, and ParticipantsCase-control analysis using the UK
General Practice Research Database (GPRD). The study included 30 601 case patients …