Differential hormonal regulation of tryptophan hydroxylase-2 mRNA in the murine dorsal raphe nucleus
JA Clark, LY Pai, RB Flick, SP Rohrer - Biological psychiatry, 2005 - Elsevier
BACKGROUND: Recently a novel tryptophan hydroxylase isoform (TPH2) was identified
and shown to be highly expressed in the central nervous system (CNS). Hormonal effects on
TPH2 mRNA expression in the rodent dorsal raphe nucleus (DRN) are unknown.
METHODS: In situ hybridization histochemistry and real-time reverse transcriptase-
polymerase chain reaction (RT-PCR) were used to assess the effects of dexamethasone or
estradiol on TPH2 mRNA levels in the DRN of C57/Bl6 mice. RESULTS: Dexamethasone …
and shown to be highly expressed in the central nervous system (CNS). Hormonal effects on
TPH2 mRNA expression in the rodent dorsal raphe nucleus (DRN) are unknown.
METHODS: In situ hybridization histochemistry and real-time reverse transcriptase-
polymerase chain reaction (RT-PCR) were used to assess the effects of dexamethasone or
estradiol on TPH2 mRNA levels in the DRN of C57/Bl6 mice. RESULTS: Dexamethasone …