Development of neuropathic pain in the rat spared nerve injury model is not prevented by a peripheral nerve block
MR Suter, M Papaloïzos, CB Berde… - The Journal of the …, 2003 - pubs.asahq.org
Background The mechanisms responsible for initiation of persistent neuropathic pain after
peripheral nerve injury are unclear. One hypothesis is that injury discharge and early ectopic
discharges in injured nerves produce activity-dependent irreversible changes in the central
nervous system. The aim of this study was to determine whether blockade of peripheral
discharge by blocking nerve conduction before and 1 week after nerve injury could prevent
the development and persistence of neuropathic pain-like behavior in the spared nerve …
peripheral nerve injury are unclear. One hypothesis is that injury discharge and early ectopic
discharges in injured nerves produce activity-dependent irreversible changes in the central
nervous system. The aim of this study was to determine whether blockade of peripheral
discharge by blocking nerve conduction before and 1 week after nerve injury could prevent
the development and persistence of neuropathic pain-like behavior in the spared nerve …