[HTML][HTML] Thermal latency studies in opiate-treated mice

N Schildhaus, E Trink, C Polson… - Journal of Pharmacy …, 2014 - journals.lww.com
Background: The change in the reaction time of a tail or paw exposed to a thermal stimulus
is a measure of nociceptive activity in laboratory animals. Tail-flick and plantar thermal
sensitivity (Hargreaves) tests are non-invasive, minimize stress, and can be used to screen
animals for phenotype and drug activity. Objective: Hargreaves testing has been widely
used in rats. We investigated its use to measure the activity of opiate analgesia in mice.
Methods: Mice were used in thermal stimulus studies at 1-5 hours and 1-5 days to test acute …