Axon degeneration is an active program of self-destruction observed in many physiological
and pathological settings. There are three Nicotinamide mononucleotide adenylyl
transferase (Nmnat, EC2. 7.7. 1) in mammals. Overexpression of Nmnat1 or Nmnat3 can
delay axon degeneration, while the role of Nmnat2 in axon degeneration remains largely
unknown. Here we found that Nmnat2 was specifically and highly expressed in brain
compared with Nmnat1 and Nmnat3. Furthermore, we found brain Nmnat2 was correlated …