Depletion of macrophages reduces axonal degeneration and hyperalgesia following nerve injury
T Liu, N van Rooijen, DJ Tracey - Pain, 2000 - Elsevier
Inflammatory mechanisms are believed to play an important role in hyperalgesia resulting
from nerve injury. Hyperalgesia following nerve injury is temporally linked with Wallerian
degeneration and macrophage recruitment, and is reduced in WLD mice, in which Wallerian
degeneration is delayed. We sought more direct evidence that macrophages contribute to
hyperalgesia and Wallerian degeneration by depleting macrophages with liposomes loaded
with dichloromethylene diphosphonate (clodronate, Cl2MDP). Rats were subjected to partial …
from nerve injury. Hyperalgesia following nerve injury is temporally linked with Wallerian
degeneration and macrophage recruitment, and is reduced in WLD mice, in which Wallerian
degeneration is delayed. We sought more direct evidence that macrophages contribute to
hyperalgesia and Wallerian degeneration by depleting macrophages with liposomes loaded
with dichloromethylene diphosphonate (clodronate, Cl2MDP). Rats were subjected to partial …