[HTML][HTML] Do high blood folate concentrations exacerbate metabolic abnormalities in people with low vitamin B-12 status?
JL Mills, TC Carter, JM Scott, JF Troendle… - The American journal of …, 2011 - Elsevier
Background: In elderly individuals with low serum vitamin B-12, those who have high serum
folate have been reported to have greater abnormalities in the following biomarkers for
vitamin B-12 deficiency: low hemoglobin and elevated total homocysteine (tHcy) and
methylmalonic acid (MMA). This suggests that folate exacerbates vitamin B-12–related
metabolic abnormalities. Objective: We determined whether high serum folate in individuals
with low serum vitamin B-12 increases the deleterious effects of low vitamin B-12 on …
folate have been reported to have greater abnormalities in the following biomarkers for
vitamin B-12 deficiency: low hemoglobin and elevated total homocysteine (tHcy) and
methylmalonic acid (MMA). This suggests that folate exacerbates vitamin B-12–related
metabolic abnormalities. Objective: We determined whether high serum folate in individuals
with low serum vitamin B-12 increases the deleterious effects of low vitamin B-12 on …