[HTML][HTML] Assay-related differences in SuPAR levels: implications for measurement and data interpretation
A Vasbinder, LM Raffield, Y Gao, G Engstrom… - Journal of …, 2023 - Springer
Soluble urokinase plasminogen activator receptor (suPAR) is an immune-derived
glycoprotein implicated in kidney disease and associated with various clinical outcomes [1].
The rising interest in exploring suPAR's role in kidney and cardiovascular disease has led to
its measurement in various cohorts [1]. Different assays have been used to measure suPAR
levels including enzyme-linked immunosorbent assays (ELISA) such as the Human uPAR
Quantikine ELISA (R&D Systems, Minneapolis, MN) and the suPARnostic ELISA (Virogates …
glycoprotein implicated in kidney disease and associated with various clinical outcomes [1].
The rising interest in exploring suPAR's role in kidney and cardiovascular disease has led to
its measurement in various cohorts [1]. Different assays have been used to measure suPAR
levels including enzyme-linked immunosorbent assays (ELISA) such as the Human uPAR
Quantikine ELISA (R&D Systems, Minneapolis, MN) and the suPARnostic ELISA (Virogates …
Assay-related Differences in SuPAR Levels: Implications for Measurement and Data Interpretation
SS Hayek, LM Raffield, Y Gao, G Engstrom… - medRxiv, 2021 - medrxiv.org
With the growing interest in studying the role of soluble urokinase plasminogen activator
receptor (suPAR) in kidney and other diseases, levels are now being measured in major
cohorts across the world through various methods, including immunoassays and through
proteomics. Reported suPAR values have however varied dramatically depending on which
assay is used. Comparing suPAR assays and their ability to discriminate risk is crucial for
the Nephrology and overall research community to guide assay choice and inform …
receptor (suPAR) in kidney and other diseases, levels are now being measured in major
cohorts across the world through various methods, including immunoassays and through
proteomics. Reported suPAR values have however varied dramatically depending on which
assay is used. Comparing suPAR assays and their ability to discriminate risk is crucial for
the Nephrology and overall research community to guide assay choice and inform …