Soluble urokinase plasminogen activator receptor and decline in kidney function in autosomal dominant polycystic kidney disease
Background Levels of soluble urokinase plasminogen activator receptor (suPAR), an
inflammation marker, are strongly predictive of incident kidney disease. Patients with
autosomal dominant polycystic kidney disease (ADPKD) experience progressive decline in
renal function, but rates of decline and outcomes vary greatly. Whether suPAR levels are
predictive of declining kidney function in patients with ADPKD is unknown. Methods We
assessed suPAR levels in 649 patients with ADPKD who underwent scheduled follow-up for …
inflammation marker, are strongly predictive of incident kidney disease. Patients with
autosomal dominant polycystic kidney disease (ADPKD) experience progressive decline in
renal function, but rates of decline and outcomes vary greatly. Whether suPAR levels are
predictive of declining kidney function in patients with ADPKD is unknown. Methods We
assessed suPAR levels in 649 patients with ADPKD who underwent scheduled follow-up for …