Receptors expressed on the plasma membrane and their interacting partners critically
regulate cellular communication during homeostasis and disease, and as such represent
main therapeutic targets. Despite its importance for drug development, receptor-ligand
proteomics has remained a daunting field, in part because of the challenges associated to
the study of membrane-expressed proteins. Here, to enable sensitive detection of receptor-
ligand interactions in high throughput, we implement a new platform, the Conditioned Media …