Flaming and fanning: the spectrum of inflammatory influences in myelodysplastic syndromes
T Banerjee, LM Calvi, MW Becker, JL Liesveld - Blood reviews, 2019 - Elsevier
The myelodysplastic syndromes (MDS) represent neoplasms derived from the expansion of
mutated clonal hematopoietic cells which often demonstrate aberrant differentiation potential
with resultant cytopenias and a propensity to evolve into acute myelogenous leukemia.
While multiple mutations have been identified which may serve as drivers of the MDS clone,
there is accumulating evidence that MDS clones and subclones are subject to modulation by
the marrow microenvironment and its inflammatory milieu. There is also a strong link …
mutated clonal hematopoietic cells which often demonstrate aberrant differentiation potential
with resultant cytopenias and a propensity to evolve into acute myelogenous leukemia.
While multiple mutations have been identified which may serve as drivers of the MDS clone,
there is accumulating evidence that MDS clones and subclones are subject to modulation by
the marrow microenvironment and its inflammatory milieu. There is also a strong link …