[HTML][HTML] The kynurenine pathway; A new target for treating maternal features of preeclampsia?
SA Worton, SL Greenwood, M Wareing, AEP Heazell… - Placenta, 2019 - Elsevier
In preeclampsia, vasospasm, oxidative stress, endothelial dysfunction, and immune
dysregulation are key mediators of maternal disease. A new time-of-disease treatment is
needed with the potential to treat these areas of pathophysiology. A review of the literature
has indicated that metabolites of the kynurenine pathway have the potential to;(i) induce
vasorelaxation of resistance arteries and reduce blood pressure;(ii) exert antioxidant effects
and reduce the effects of poly-ADP ribose polymerase activation (iii) prevent endothelial …
dysregulation are key mediators of maternal disease. A new time-of-disease treatment is
needed with the potential to treat these areas of pathophysiology. A review of the literature
has indicated that metabolites of the kynurenine pathway have the potential to;(i) induce
vasorelaxation of resistance arteries and reduce blood pressure;(ii) exert antioxidant effects
and reduce the effects of poly-ADP ribose polymerase activation (iii) prevent endothelial …