Collagen type-V is a danger signal associated with primary graft dysfunction in lung transplantation
L Zaffiri, RJ Shah, RS Stearman, K Rothhaar… - Transplant …, 2019 - Elsevier
Background Primary graft dysfunction (PGD) is the leading cause of early mortality after lung
transplantation. Anti-collagen type-V (col (V)) immunity has been observed in animal models
of ischemia-reperfusion injury (IRI) and in PGD. We hypothesized that collagen type-V is an
innate danger signal contributing to PGD pathogenesis. Methods Anti-col (V) antibody
production was detected by flow cytometric assay following cultures of murine CD19+
splenic cells with col.(V). Responding murine B cells were phenotyped using surface …
transplantation. Anti-collagen type-V (col (V)) immunity has been observed in animal models
of ischemia-reperfusion injury (IRI) and in PGD. We hypothesized that collagen type-V is an
innate danger signal contributing to PGD pathogenesis. Methods Anti-col (V) antibody
production was detected by flow cytometric assay following cultures of murine CD19+
splenic cells with col.(V). Responding murine B cells were phenotyped using surface …