[HTML][HTML] Donor-derived exosomes with lung self-antigens in human lung allograft rejection
The immunological role of exosomes in allograft rejection remains unknown. We sought to
determine whether exosomes are induced during lung allograft rejection and to define the
antigenic compositions of HLA, lung-associated self-antigens (SAgs) and microRNAs
(miRNAs). Exosomes were isolated from sera and bronchoalveolar lavage fluid from 30 lung
transplant recipients (LTxRs) who were stable or who had acute rejection (AR) or
bronchiolitis obliterans syndrome (BOS). Exosomes were defined by flow cytometry for …
determine whether exosomes are induced during lung allograft rejection and to define the
antigenic compositions of HLA, lung-associated self-antigens (SAgs) and microRNAs
(miRNAs). Exosomes were isolated from sera and bronchoalveolar lavage fluid from 30 lung
transplant recipients (LTxRs) who were stable or who had acute rejection (AR) or
bronchiolitis obliterans syndrome (BOS). Exosomes were defined by flow cytometry for …