Effect of oral insulin on prevention of diabetes in relatives of patients with type 1 diabetes: a randomized clinical trial
Importance Type 1 diabetes requires major lifestyle changes and carries increased
morbidity and mortality. Prevention or delay of diabetes would have major clinical effect.
Objective To determine whether oral insulin delays onset of type 1 diabetes in autoantibody-
positive relatives of patients with type 1 diabetes. Design, Setting, and Participants Between
March 2, 2007, and December 21, 2015, relatives with at least 2 autoantibodies, including
insulin autoantibodies and normal glucose tolerance, were enrolled in Canada, the United …
morbidity and mortality. Prevention or delay of diabetes would have major clinical effect.
Objective To determine whether oral insulin delays onset of type 1 diabetes in autoantibody-
positive relatives of patients with type 1 diabetes. Design, Setting, and Participants Between
March 2, 2007, and December 21, 2015, relatives with at least 2 autoantibodies, including
insulin autoantibodies and normal glucose tolerance, were enrolled in Canada, the United …