Respiratory infections in early life and the development of islet autoimmunity in children at increased type 1 diabetes risk: evidence from the BABYDIET study
A Beyerlein, F Wehweck, AG Ziegler… - JAMA pediatrics, 2013 - jamanetwork.com
Importance There is evidence for a role of infections within the pathogenesis of islet
autoimmunity and type 1 diabetes mellitus (T1D), but previous studies did not allow
assessment of potential critical time windows in this context. Objective To examine whether
early, short-term, or cumulative exposures to episodes of infection and fever during the first 3
years of life were associated with the initiation of persistent islet autoimmunity in children at
increased T1D risk. Design Prospective cohort study with daily infection records and regular …
autoimmunity and type 1 diabetes mellitus (T1D), but previous studies did not allow
assessment of potential critical time windows in this context. Objective To examine whether
early, short-term, or cumulative exposures to episodes of infection and fever during the first 3
years of life were associated with the initiation of persistent islet autoimmunity in children at
increased T1D risk. Design Prospective cohort study with daily infection records and regular …