[HTML][HTML] Emerging mechanisms and applications of low-dose IL-2 therapy in autoimmunity
P Zhou - Cytokine & Growth Factor Reviews, 2022 - Elsevier
Abstract Interleukin 2 (IL-2) is a pleiotropic cytokine that elicits both immunogenic and
tolerogenic immune response essential for homeostasis. Initial clinical application of IL-2
based therapy was hampered by its function on broad spectrum of cells expressing
corresponding receptors, which exerts uncontrolled side effects in clinical trials. While recent
progress on structural modification or adjusted regimen of IL-2, revolutionized the use of IL-2
in immunomodulation process that requires stringent selection of effector cells, such as …
tolerogenic immune response essential for homeostasis. Initial clinical application of IL-2
based therapy was hampered by its function on broad spectrum of cells expressing
corresponding receptors, which exerts uncontrolled side effects in clinical trials. While recent
progress on structural modification or adjusted regimen of IL-2, revolutionized the use of IL-2
in immunomodulation process that requires stringent selection of effector cells, such as …
