[HTML][HTML] FADS3 is a Δ14Z sphingoid base desaturase that contributes to gender differences in the human plasma sphingolipidome
Sphingolipids (SLs) are structurally diverse lipids that are defined by the presence of a long-
chain base (LCB) backbone. Typically, LCBs contain a single Δ4E double bond (DB)(mostly
d18: 1), whereas the dienic LCB sphingadienine (d18: 2) contains a second DB at the Δ14Z
position. The enzyme introducing the Δ14Z DB is unknown. We analyzed the LCB plasma
profile in a gender-, age-, and BMI-matched subgroup of the CoLaus cohort (n= 658).
Sphingadienine levels showed a significant association with gender, being on average∼ …
chain base (LCB) backbone. Typically, LCBs contain a single Δ4E double bond (DB)(mostly
d18: 1), whereas the dienic LCB sphingadienine (d18: 2) contains a second DB at the Δ14Z
position. The enzyme introducing the Δ14Z DB is unknown. We analyzed the LCB plasma
profile in a gender-, age-, and BMI-matched subgroup of the CoLaus cohort (n= 658).
Sphingadienine levels showed a significant association with gender, being on average∼ …