Incidence and prediction of HBsAg seroclearance in a prospective multi‐ethnic HBeAg‐negative chronic hepatitis B cohort
Methods The Hepatitis B Research Network (HBRN) is a prospective cohort including 1240
untreated HBeAg‐negative patients (1150 adults, 90 children) with median follow‐up of 5.5
years. Incidence rates of HBsAg loss and hepatitis B surface antibody (anti‐HBs) acquisition
were determined, and a predictor score of HBsAg loss using readily available variables was
developed and externally validated. Results Crude incidence rates of HBsAg loss and anti‐
HBs acquisition were 1.6 and 1.1 per 100 person‐years (PY); 67 achieved sustained HBsAg …
untreated HBeAg‐negative patients (1150 adults, 90 children) with median follow‐up of 5.5
years. Incidence rates of HBsAg loss and hepatitis B surface antibody (anti‐HBs) acquisition
were determined, and a predictor score of HBsAg loss using readily available variables was
developed and externally validated. Results Crude incidence rates of HBsAg loss and anti‐
HBs acquisition were 1.6 and 1.1 per 100 person‐years (PY); 67 achieved sustained HBsAg …